The hospital comprises 144 beds, 14 operating theatres, and is staffed by over 200 surgeons and medical specialists.

The hospital provides inpatient and outpatient services and complements Macquarie University's existing specialisations including cognitive neuropsychology, telemedicine, teleradiology, speech therapy and audiology.

[2] It has Australia's first Gamma Knife for advanced radiation therapy, and a cyclotron for the production of radioactive isotopes for medical imaging.

The Clinic building is also home to the university's Faculty of Medicine and Health Sciences.

The five-storey research and clinic building is linked to the hospital proper by an air bridge.