Macrorhizodus is an extinct genus of mackerel shark which lived from the early Eocene to early Oligocene epoch of the Paleogene period.

It is known from isolated teeth and vertebral centra as well as at least two associated dentitions.

[2] The genus is composed of the following species: This genus appears to have undergone anagenesis, making it difficult to draw lines between species.

The early Oligocene species Macrorhizodus flandricus ascribed to this genus now usually considered to be a synonym of Isurus desori, sometimes styled Isurus desori flandrica.

This confusion stems from the proximity of Macrorhizodus to Isurus.