In "Grim Hunt", she is attacked by Ana Kravinoff and her mother Sasha, who kills her, but before she dies she is able to pass her powers of precognition as well as her blindness on to Julia Carpenter, who becomes the next Madame Web.

Rachel Dratch voices "C. Weber", a character loosely based on Madame Web, in Spider-Man: Across the Spider-Verse (2023), while Dakota Johnson portrayed Cassie Webb in the eponymous 2024 film.

Madame Web was created by writer Dennis O'Neil and artist John Romita Jr., and first appeared in The Amazing Spider-Man No.

[3] Born in Salem, Oregon, Cassandra Webb is a paralyzed, blind, telepathic, clairvoyant, and precognitive mutant[1] who works as a professional medium.

After being stricken with myasthenia gravis, she is connected to a life support system designed by her husband Jonathan Webb, which includes a series of tubes shaped like a spider-web.

story arc, she contacts Spider-Man for assistance when Black Tom Cassidy dispatches the Juggernaut to capture her, hoping to exploit her psychic abilities against the X-Men.

This triggers a fight between Spider-Man and the Juggernaut, who is subsequently trapped in a construction site's wet cement foundation.

[6] The resulting mental trauma, however, means that Madame Web apparently loses her memory of Spider-Man's secret identity.

However, since House of M (in which she appears young), Cassandra seemingly loses her mystical enhancements and reverts to her aged self, though her myasthenia gravis remains gone.

While still bound in a chair, she apologizes to a then-unconscious Mattie,[11] who is later killed by Sasha Kravinoff as part of a sacrificial ritual that revives Grim Hunter.

[12] At the conclusion of "Grim Hunt", Sasha Kravinoff slashes the throat of Madame Web, believing that Cassandra was deceiving her and knew the outcome of events that transpired.

She is sensitive to psychic energies, allowing her to sense the presence of psionic powers in others, to see the area surrounding her, and events which take place far away from her.