Made In Space was founded in August 2010 by Aaron Kemmer, Jason Dunn, Mike Chen, and Michael Snyder, during that year's Singularity University Graduate Studies Program.

In the spring of 2011, Made In Space created their 3D Printing Lab at the NASA Ames Research Center on Moffett Field in Mountain View, California.

In May 2014, NASA awarded Made In Space a Phase 1 SBIR contract for the development of a recycler unit to use with the 3D printer the ISS and for their microwell project.

[4] In June 2014, Made In Space showcased their in-space manufacturing capabilities at the White House Maker Faire.

[5] On 21 September 2014 at 1:52 a.m. EDT (05:52 UTC), Made In Space's Zero-G printer was launched from Cape Canaveral, Florida to the ISS on board SpaceX CRS-4.

On 11 December 2014, Made In Space's the printer's first functional application was announced: a buckle developed by NASA astronaut Yvonne Cagle.

Made In Space Europe will work on the development of a low-cost modular robotic arm for in-space applications.

[15] In 2014, NASA selected Made In Space as one of several companies to develop a recycler for 3D printed material on the ISS.

[17][18] Made In Space worked with Northrop Grumman and Oceaneering International to build and demonstrate Archinaut (OSAM-2), a versatile in-space robotic precision manufacturing and assembly system.

MIS performed ground testing of a central spar onto which rolled up solar arrays can be extended and locked into place.

Based on the results from initial experiments and market demand, Made In Space plans to develop and operate larger-scale microgravity production facilities for ZBLAN and other microgravity-enabled materials.

The advantage of fiber optics produced in microgravity are much lower signal loss capabilities, which benefit long-haul communications, medical research, super-computing, and many other industries and applications.