Humphries is best known for her roles as Rita Arguelles in the television drama Bituing Walang Ningning (2006), and as Brenda Smith in the youth-oriented program Abt Ur Luv (2006).
Madeleine Lauren Humphries was born in San Francisco, California to a Filipina mother and a French-American father of Italian descent.
Her first recurring guest role came in late 2003, when she was cast as a fashion model named "Paris" in the youth-oriented TV show Berks.
In 2004, Humphries appeared in a supporting role in her first movie, My First Romance, as a friend of the lead character portrayed by Heart Evangelista.
In the same year, Humphries was cast as "Rita Arguelles" in the primetime drama series Bituing Walang Ningning, which starred Sarah Geronimo and Angelika dela Cruz.
Humphries also appeared that same year in supporting roles in two well-received Star Cinema movies, D' Lucky Ones and First Day High.
Humphries was also cast as one of the four lead characters in the youth-oriented TV series Star Magic Presents: Abt Ur Luv, which began airing in November 2006.
The show launched her new loveteam with Victor Basa, won Best Youth Oriented Program at the 21st PMPC Star Awards (2007), and aired a total of 57 episodes.
After Palos ended, Humphries also appeared on Ligaw na Bulaklak, an afternoon drama series that began airing on the ABS-CBN network in May 2008.
[2] In 2003 shortly after her launch, Humphries began appearing in local style and fashion magazines intended for the teen market.