He represented the Nizamabad constituency of Telangana and is a member of the Indian National Congress (INC) political party.

He also obtained an LLB from the University of Delhi in 1985 and LLM from P. G. College of Law, Hyderabad in 1989.

Moved by the plight of farmers committing suicides due to crop failures and high debts, he left US and returned to India.

He has a law firm in New York and Atlanta, still actively working through remote operations and few visits every few months In 2004, Madhu Yaskhi was elected as a Member of Parliament from Nizamabad.

He founded Madhu Yaskhi Foundation in 2003 and donates a portion of his income to the foundation to provide financial assistance to the poor farmers and educate their children up to 12th standard and also to provide health care facilities with the assistance of his wife Dr. Shuchee Yaskhi.