[2] She debuted in Kannada mythological series and played the role of the goddess Lakshmi in the 2018 show Jai Hanum.
In 2019, she debuted into the Tamil television industry in the soap opera Piriyadha Varam Vendum playing the lead and dual role as Durga / Amaravathi which was aired on Zee Tamil.
[4] She later returned to Telugu television and appeared in the serial No.1 Kodalu playing the role as Saraswathi.
[5] In 2022, Madhumitha was cast in the lead role in the Tamil soap opera Ethirneechal.
In February 2024, Madhumitha was charged with reckless driving, after hitting a police officer on duty.