[2] The film stars Joju, Shruti Ramachandran, Nikhila Vimal, Arjun Ashokan, and Indrans in important roles.

[4][5] The movie mainly focuses on Sabu and Kevin, the two bystanders at Kochi Medical College Hospital.

The friendship between the two and other bystanders, the stories shared by each of them, and how they give strength and support to each other to recover from the problems they face in life become the premise of the movie.

The director actually announced another movie, Insha Allah starring Joju George as his second directional.

The News Minute wrote that, "Ahammed Khabeer’s story is about hospital bystanders, which he has directed with beautiful visuals, especially of the food.

Joju George with the help of the unfailing Indrans and a talented crew of younger actors, gives us a cosy ride with Madhuram.

"[22] Sify rated the movie with 3.5 on 5 and wrote that, "Madhuram has its spectacular moments, which makes this a genuine effort.

"[23] Baradwaj Rangan of Film Companion wrote that, "Madhuram is a set of love stories as sweet as the title.