[3] Madison County is included in the Jackson, TN Metropolitan Statistical Area.

The county was part of lands the United States purchased from the Chickasaw in 1818.

[7][8] Lake Graham, a large 500 acre reservoir primarily intended for recreation and wildlife habitat, is located in the county 5 miles east of Jackson.

[9] As of the 2020 United States census, there were 98,823 people, 38,930 households, and 25,748 families residing in the county.

26.20% of all households were made up of individuals, and 9.30% had someone living alone who was 65 years of age or older.

West Tennessee Healthcare (Jackson-Madison County General Hospital District), created by a law passed by the Tennessee General Assembly in 1949, serves as the public hospital system of the county.

[21] This is the Madison County to which Kenny Rogers refers in his song "Reuben James".

Union University is a private school affiliated with the Tennessee Baptist Convention.