It is set in 3000 AD, where Catholic priest Izaya and his mass-murderer teammate Kyou fight to save the world from a series of natural disasters.

It is the year 3000 AD and Airishuu Izaya Luke is a Catholic priest of the Cult of Saint Ruka.

Kyou has spent the past three years imprisoned in Izaya's church, with no memory of his murderous nature.

Kyou forcefully takes Izaya with him to be his Suppressor and they go to a big city to turn in Sae's head for his bounty.

Afterwards, she helps Izaya escape, but right when he's about to leave, Miyabi's hawk comes followed by Kyou and Oboro.

He goes off after her, and arrives as the man who bought her attempts to kill her, as he was a bounty hunter who discovered she was really Miyabi.

The blood and Izaya being injured awaken Miyabi's murderous side and she kills the man.

Miyabi decides to come along with the group to protect Izaya, who turns out to be the younger brother of the man she fell in love with.

While there, they are ambushed again and Izaya finds out that the assassins are from his religion, which is supposed to abhor murder and violence.

He still strongly dislikes fighting; however, he resolved to put himself in danger's way because he wishes to assess for himself what is good and what is evil.

It is revealed that they used Izaya's older brother in order to make criminals so the assassins may kill them in the name of god.

The Madness members had chips implanted in their brains which was made to make them forget anything but their blood desires.

Izaya begs them to come bag safely, at which Kyou responds that he won't die till he does him.

Kyou explains that Kai kept them there for 2 years to remove the chips out of their heads so it delayed them from picking Izaya up.

He was a very strong Believer in his religion which advocates God and judgment; that the murder of people is wrong.

He still strongly dislikes fighting however he resolved to put himself in danger's way because he wishes to assess for himself what is good and what is evil.

Kyou (きょう, Kyō) is a former mass murderer of the group Madness who teams up with Izaya.

He has trouble recollecting memories of his past but he remembers that was born inside a cell of some sort and as a boy had a lust to kill.

Like all members of Madness, he has a chip that is inserted into his brain which controls his actions if activated.

She is a beautiful, albino woman who left Kyou for dead because she didn't want to kill anymore.

Like Kyou, though, sometimes her bloodlust gets the better of her though this is due to the chip which Ruka implanted inside her brain.

[3] M. M. Blair feels that Madness has plot elements from seinen and shonen works and also has more "bloody scenes".