The Santa Maria in Porto Altarpiece is a painting by the Italian Renaissance painter Ercole de' Roberti, executed in 1479-1481 and housed in the Pinacoteca di Brera, Milan, northern Italy.

The base is decorated by tiles (with the Massacre of the Innocents, Adoration of the Magi and the Presentation in the Temple) which simulated antique bas-reliefs and were inspired by the altar of the Basilica of Saint Anthony of Padua by Donatello.

The base supports columns with mouldings and decorations of garlands, dishes and marble rings, while in the background is a stormy sea.

The latter is a reference to the legendary foundation of Santa Maria in Porto, when the Crusader Pietro degli Onesti, after escaping a shipwreck, made a vow to entitle a church to the Virgin Mary in exchange for his miraculous salvation.

The four saints are St. Augustine (below left), the blessed Pietro degli Onesti (below right), St. Elizabeth and St. Anne (above, at the sides of the Virgin).