He was profiled in Vasari's Le Vite delle più eccellenti pittori, scultori, ed architettori.
According to Vasari: Ercole had an extraordinary love of wine, and his frequent drunkenness did much to shorten his life, which he had enjoyed without any accident up to the age of forty, when he was smitten one day by apoplexy, which made an end of him in a short time.
Ercole's first mature works are his contributions to the Griffoni Chapel for the San Petronio Basilica in Bologna: a predella depicting the Miracles of St Vincent Ferrer (c. 1473) (now in the Pinacoteca of the Vatican),[2] and lateral pilasters for the altarpiece commissioned from del Cossa.
In 1480, Ercole created a large altarpiece with a Madonna and Child Enthroned with Saints for Santa Maria in Porto in Ravenna, which is now in the Pinacoteca di Brera, Milan.
Ercole's painting of Saint Jerome in the Wilderness from this period is in the collection of the J. Paul Getty Museum, Los Angeles.