Madonna del Rosario was a painting made of egg tempera on a wood panel nearly 11 feet in height.

Damaskinos was influenced by the works of Venetian masters Palma Giovane, Paolo Veronese, Tintoretto and Titian.

Pope Pius V issued Consueverunt Romani Pontifices on September 17, 1569, a papel degree formalizing the 15 mysteries of the Rosary.

[9][10][11] The Madonna del Rosario by Damaskinos is at the Monastery of San Benedetto in Conversano, Italy 65 kilometers away from Molfetta in the same Metropolitan region of Bari.

[14] The Virgin Mary sits elevated on stairs in the middle ground to her left and right are kneeling ecclesiastical figures.

Two angels hold up a mystical garment behind the Virgin Mary which radiates both celestial figures are busy distributing rosary to their left and right infant Jesus is naked resembling the putti.

[13][15] Damaskinos' anatomical detail and complex three-dimensional figures escape the realm of the traditional maniera greca and the artist incorporates the prevalent Venetian painting styles.

The altar that houses the painting is also adorned with statues, spiral-decorated columns, and naturalistic species of birds, fruits, and flowers.