Molfetta (Italian: [molˈfetta]; Molfettese: Melfétte) is a town located in the northern side of the Metropolitan City of Bari, Apulia, southern Italy.

The origins of the city can be traced to a small fishing port; antique graves testify to a fisherman's village in the fourth century BC.

The first indication of a toponym on the coast between Turenum (Trani) and Natiolum (Giovinazzo) is in the Itinerarium Provinciarum Antonini Augusti, edited from a third-century core.

These wars provoked death and destruction in the whole south of Italy: the Sack of Molfetta at the hands of the French, 18–19 July 1529, was an episode that stalled the economic rebirth of the city.

Personalities from Molfetta include Cardinal Angelo Amato, Rossella Biscotti (artist), Luigi Capotorti (19th-century composer), Leonardo Andriani (immigrant), Corrado Giaquinto (Rococo painter), Domenico Leccisi (notorious for stealing Mussolini's corpse), Riccardo Muti (conductor), Girolamo Minervini (assassinated magistrate), Caparezza (rapper), Gaetano Salvemini (anti-fascist politician and writer), and Vitangelo Spadavecchia (goalkeeper).