[1] The Government General Hospital was established on 16 November 1647 to treat soldiers of the British East India Company.

The foundation stone for the new building of the college was laid by the then Chief Minister of Tamil Nadu, M. Karunanidhi, on 28 February 2010.

[6] A new campus with a six-storeyed building for Madras Medical College was built on land covering 325,000 square feet (30,200 m2) on the erstwhile central prison premises in 2010 and was completed in 2012.

[citation needed] The old MMC buildings presently house the college of pharmacy, school of nursing and also accommodate students of the recently added courses of audiology, speech learning and pathology, radiotherapy and radio diagnosis.

[7] Since 1857, the college has been affiliated to the University of Madras and all degrees of Health Sciences were awarded by the same until 1988 when the Tamil Nadu Dr. M.G.R.

[11] Madras Medical college hosts inter-college cultural extravaganza known as "REVIVALS"[12] and the annual inter-medical sports meet known as "ENCIERRO".