Unlike many of the Trecento composers, he was not a Florentine, since he does not appear in the chronicle by Filippo Villani, which includes all of the musicians active there throughout the 14th century.
Piero was possibly from Assisi, and is known to have been in Milan and Verona, employed by the Visconti and della Scala families, respectively; in addition, he may have been in Padua with Antonio della Scala before going to Verona, along with composer Giovanni da Cascia (Giovanni da Firenze).
He was also associated with composer Jacopo da Bologna during this period, and the three composers appear to have engaged in a contest to set the same madrigal text, effectively forming a madrigal cycle: the date of this contest was in or after 1349, very near the end of Piero's life.
There is no trace of any activity by Piero, or Giovanni da Cascia, after 1351; one or both composers may have died in the Black Death which swept through northern Italy during this time.
A total of eight compositions by Piero have survived, plus two more cacce which have been attributed to him based on stylistic similarities.