In the animated series SilverHawks, she voiced not only the villainess Melodia and the heroine Steelheart/Emily Hart, but all of the female characters; she also worked on the Karate Kat and Mini-Monsters segments of The Comic Strip.

She has appeared in many other television programs, including Drake & Josh, ER, The X-Files, The War at Home, Will & Grace, Jack and Jill, How I Met Your Mother and Curb Your Enthusiasm.

In 1997, Wheeler voiced Harley Quinn's replacement in the Batman: The Animated Series episode "Joker's Millions".

In 1998, she appeared in the remake of Disney's The Parent Trap, playing the younger of a mother-daughter pair of camp counselors.

Wheeler provided the voice of Odile in Barbie of Swan Lake, and Trinette in the animated sitcom Archer.