[4] The series revolves around the adventures of George Beard and Harold Hutchins, two best friends who are devoted pranksters and aspiring comic book artists.

Most episodes deal with a threat to the school brought about by an ordinary person, often a teacher, being turned into a monster depicted in George and Harold's comics through intentionally contrived coincidences.

A cyborg future version of George and Harold's nemesis Melvin takes over the school and replaces Mr. Krupp so he can get his younger self into Eliteanati Academy.

In April 2000, Dav Pilkey sought to adapt Captain Underpants into a possible television series, having imagined Chris Farley in the titular role prior to his death.

[7][8] Originally titled "Captain Underpants and the Epic Tales of George and Harold",[9] it premiered on the streaming service on July 13, 2018,[10] and was executive-produced by Peter Hastings.