It is a large forest tree of the Eastern United States and Southern Ontario in Canada.

They can become quite massive: the United States national (and presumed world) champion in Stark County, Ohio measures eight feet (2.4 m) in diameter and 96 ft (29 m) tall.

They are tricky to transplant due to their coarse, fleshy root system and should be planted shallow and moved in early spring with a good soil ball.

In the timber trade, the wood of this tree is interchangeable with that of the related tuliptree (Liriodendron tulipifera).

Magnolia acuminata has been used in hybridizing new varieties that share its yellow flower color and cold hardiness.