This is the first season not to feature co-developer Peter M. Lenkov as co-showrunner and executive producer after he was fired over allegations for a toxic work environment.

[21] On July 7, 2020, it was revealed that co-showrunner, executive producer, and co-developer Peter M. Lenkov would not have any involvement in the season after being fired from CBS over toxic work environment allegations.

[22] Lenkov was originally expected to continue work on the series for another year after signing a three-year deal with CBS Television Studios in 2018.

[28] Numerous production staff moved to the series also following the cancellation of Hawaii Five-0 including co-showrunner of its final season, David Wolkove, a line producer, and editors.

[31] On October 27, 2020, it was reported that the season would have a reduced episode order of sixteen-episodes as a result of the COVID-19 pandemic.

[33] On July 1, 2020, it was revealed that the series was eyeing a delayed mid-August start date to begin filming as a result of the COVID-19 pandemic.

[40] Due to the limited numbers of extras allowed on the set, crowd replication visual effects were used as a replacement.

[43] On October 16, 2020, it was announced that Jay Ali had been cast in a recurring role for the season as Dr. Ethan Shah, a love interest for the character of Juliet Higgins.

[47] Dennis Chun, who portrayed various minor characters on the original series also returned as Honolulu Police Department Sergeant Duke Lukela.

[48] Christopher Thornton, Kimee Balmilero, and Shawn Mokuahi Garnett continue to recur in the series after being introduced in the first season.

[55] The season aired three episodes in December 2020 before taking its regular mid-season break and returned in January 2021.

[57] When CBS chose to air a rebroadcast of Oprah with Meghan and Harry in its place the episode was rescheduled to be broadcast on March 26.