Together with Cerrillos, Machuelo Arriba, Maragüez, Montes Llanos, Portugués, Sabanetas, and Tibes, Magueyes is one of the municipality's eight interior barrios.

[7][8] In terms of barrio-to-barrio boundaries, Magueyes is bounded on the North by Guaraguao, on the South by Magueyes Urbano and Portugues Urbano, in the West by Marueño and Canas, and on the East by Tibes and Portugués.

[12] Running all along the full length of Magueyes is Rio Canas, which effectively divides the barrio in two almost identically sized areas.

The communities of Corral Viejo, Las Delicias, El Madrigal, Estancias de Country Club, Lomas de Country Club, Granada Hills, Reparto Lomas del Sol, Reparto El Valle, and (Parcelas) Magueyes proper are located in Magueyes.

PR-501 also makes a short appearance in the lower southwestern part of the barrio.