She started her journalism career by covering Israel's military campaign on the Gaza Strip in July 2014.

[citation needed] Al-Hussaini has worked as a reporter in conflict zones, notably writing about human rights violations in the Occupied Palestinian territories.

[citation needed]writes for international newspapers, most notably "Middle East Eye",[3] "The New Humanitarian"[4] and "Rory Peck".

[5] Until 2019, she held the position of executive director of the Euro-Mediterranean Human Rights Monitor's Regional Office in the Palestinian Territories.

However, after the conservative Washington Free Beacon published an article claiming that Al-Haissani had made Tweets supporting Hamas' attacks on Israel on Oct 7, 2023 and had shared a cartoon from Iran's International Holocaust Cartoon Competition, the IWMF announced it had revoked her award, stating that it had "learned of comments made by Maha Hussaini in past years that contradict the values of our organization.