In the 1750s, Peter and Michael Shaffer had land grants along and near the mouth of Mahantango Creek.
A rock formation known as the Marcellus black slate forms visible outcrops at the headwaters of the creek.
[11] There are also no-till planting practices being done in the creek's watershed to reduce the amount of sediment flowing from it into the Susquehanna River and Chesapeake Bay.
[14] Mahantango Creek's name comes from the Delaware word mahantongo, which means "where we had plenty to eat".
It was apparently named after a group of Native Americans had a large meal on the creek.
Michael Witmer gained access to a tract of land on Mahantango Creek around 1770.
[13] Historically, there were twelve gristmills and fourteen sawmills on Mahantango Creek and its tributaries.
[10] In March 1901, flooding and ice jams severely damaged a number of bridges over Mahantango Creek.
[18] The Mahantango Creek Confluence Pools are a series of small pools located near Mahantango Creek in Susquehanna Township, Juniata County and Snyder County.
[19] Additionally, there are vernal pools on the tributary West Branch Mahantango Creek.
[17] Brook trout have inhabited North Branch Mahantango Creek in the past.