The university was established on 3 June 1998 by the state Government of Maharashtra through an ordinance.

The State Legislature passed the ordinance and the Maharashtra University of Health Sciences was declared open by the governor of Maharashtra on June 10, 1998.

All colleges and institutions imparting education in health science in the state of Maharashtra have been affiliated to this new university under Section 6(3) of the Act.

[2] Postgraduate courses awarded are versatile including Doctor of Medicine (M.D.)

[3] Medical colleges affiliated with the university, as of July 2019[update]:[4]