Mahasarakham University (MSU; Thai: มหาวิทยาลัยมหาสารคาม; RTGS: Mahawitthayalai Mahasarakham, pronounced: má-hăa wít-tá-yaa-lai má-hăa-săa-rá-kaam) is a Thai public university in Maha Sarakham province, about 470 kilometres from Bangkok.

[3] MSU is the only Thai university to offer postgraduate programs in paleontology and a Bachelor of Arts in the Khmer language.

To extend its academic services to remote communities, MSU has had 15 academic service centers in the northeastern region, later reorganized into two centres in Nakhon Ratchasima province and Udon Thani province.

[6] As a regional education center, Maha Sarakham is known as the "Taxila (or Takshashila) (a Hindu and Buddhist centre of learning in ancient India) of Isan".

This campus with a total area of 1,300 rai (210 ha; 510 acres) hosts new buildings and facilities to serve the education community and houses the main administrative center and most of the academic faculties, colleges, and research institutes of the university.