Her television debut was Mohe Rang De on Colors TV and she appeared in CID, Aahat, Miley Jab Hum Tum and Jhansi Ki Rani as a child artiste.

Mahima said in an interview that reaching this point in her career was not easy and that she had participated in more than 500 auditions prior to Sapne Suhane Ladakpan Ke.

[7] In 2015, Makwana appeared in an episodic role in Zing's youth show Pyaar Tune Kya Kiya as Mandira opposite Nikhil Chaddha.

"[11] In 2023, Makwana played Devika, an urbane, social media manager in Nitesh Tiwari's Tumse Na Ho Payega.

Grace Cyrill of India Today wrote, "Mahima Makwana's character has a very trendy job of as a social media manager for celebrities.

"[12] While Dhaval Roy of Times Of India wrote, she "effortlessly essays her character as a practical young woman who doesn't compromise on settling for a boyfriend who is not up to her standard, even if it means being in and out of relationships.

"[13] In 2024, Makwana played Mahika Nandy in the Dharma Productions series Showtime co-starring Naseeruddin Shah and Emran Hashmi.