She holds a part-time appointment in the Department of Neurosurgery within the University of Rochester Center for Translational Neuromedicine, where she is the principal investigator of the Division of Glial Disease and Therapeutics laboratory.
[3] In 2013, Nedergaard discovered the glymphatic system, a network of channels in the brain whose purpose is to eliminate toxins using cerebrospinal fluid (CSF).
[5] Subsequent research by Nedergaard and colleagues has revealed that the aquaporin-4 water channel protein plays a crucial role in modulating the flow of CSF between the perivascular space and the brain interstitium.
[7] Presently, Nedergaard's lab focuses on neuron-glia interactions, the glymphatic system, astrocyte evolution, cerebral blood flow regulation, chronic pain, and the role of glia after stroke or spinal cord injury.
[9] In 2014, she accepted a Novo Nordisk Foundation Laureate Research Grant in 2014 to assist in establishing a Center for Basic and Translational Neuroscience at the University of Copenhagen.