Main-à-Dieu (population 242) is a community located in Nova Scotia's Cape Breton Regional Municipality.

Main-à-Dieu has a rich history tied to both its French origins and its role in the region's maritime industry.

It was originally settled by French fishermen in the 17th century, likely attracted by the abundance of fish in the area's waters.

These early settlers engaged in the lucrative cod fishery, establishing a thriving fishing community.

The centre includes the Fisherman's Museum, The Big Wave Café and the local library, all of which had previously been housed elsewhere in the community.