The Main Street Commercial Historic District is located in Jefferson, Wisconsin.

The district is made up of Jefferson's old downtown, including the 1860 Jefferson House hotel,[2] the 1869/1907 Neuer Saloon/Sample room,[3] the 1884 Italianate Beinfang Block,[4] the 1892 Queen Anne Fisher Building,[5] the 1896 Gothic Revival Stoppenbach Meat Market,[6] the eclectic 1902 Jefferson County Bank,[7] the 1911-12 Neoclassical Farmers & Merchants Bank,[8] the 1914 Craftsman-style C&NW Depot,[9] and the 1930 Art Deco Ziegler Garage.

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