The 2nd constituency of Maine-et-Loire (French: Deuxième circonscription de Maine-et-Loire) is a French legislative constituency in the Maine-et-Loire département.

Like the other 576 French constituencies, it elects one MP using a two round electoral system.

The 2nd Constituency of Maine-et-Loire covers the centre of the department including some southern parts of Angers.

For many years the seat had been held by deputies from the centre-right, before being claimed by the Socialist Party in 2007.

At the 2017 election the constituency was won by Stella Dupont a former PS regional councillor, pushing her former party to 7th place and just over 3% of the vote.