The 5th constituency of Maine-et-Loire (French: Cinquième circonscription de Maine-et-Loire) is a French legislative constituency in the Maine-et-Loire département.

Like the other 576 French constituencies, it elects one MP using a two round electoral system.

The 5th Constituency of Maine-et-Loire is situated in the south of the department.

Politically the seat has historically favoured centre right candidates until the En Marche!

landslide of 2017 when their candidate, Denis Masséglia, came close to winning in the first round.