It is a secondary highway which runs for 9.3 miles (15.0 km) between U.S. Route 1 (US 1) in Presque Isle and US 1A in Easton.

SR 10 is signed as an east-west highway but follows an odd staircase-shaped alignment.

SR 10 begins in Presque Isle at the corner of Main and Academy Streets and heads southeast through the town.

The highway continues eastward to meet its eastern terminus at US 1A, just two miles (3.2 km) west of the Canada–US border.

[2] The roadway continues east as Ladner Road, which runs to the Easton/River de Chute border crossing and ultimately connects with New Brunswick Route 560.