After traveling one block east along Bond Street, SR 104 proceeds north along Water Street and the west bank of the Kennebec River.

North of the downtown area, it has an interchange with Interstate 95 at its exit 130.

It continues ten miles (16 km) north to its northern terminus at US 2/US 201/SR 201A in Skowhegan.

Sometime in the early 2010s, its designation was removed from State Street, after a change which prohibited traffic traveling south on 104 from turning left onto State St. from Bond St. eliminating SR 104 from the concurrency and shortening its length by approximately 0.8 miles (1.3 km).

US 2 east / US 201 north (Main Street) to SR 150 – Solon, Canaan