State Route 105 (SR 105) is a highway in the south-central part of the U.S. state of Maine.

SR 105 begins in Augusta at Cony Circle where it intersects U.S. Route 201 (US 201), US 202, and State Routes 9, 17, and 100.

It continues east approximately for 48 miles (77 km) until it terminates at US 1 in Camden.

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