State Route 116 (SR 116) is part of Maine's system of numbered state highways, located in Penobscot County.

It runs for 56.42 miles (90.80 km) from Old Town to Medway.

It heads east towards the Penobscot River, running parallel with it to the junction with State Routes 6 and 155 in Howland.

The route heads northwest, crossing the Penobscot River again.

The route then turns right from the Mattamiscontis Road intersection to the town of Chester.