The route heads east, past the southern edge of Range Ponds State Park and the Poland Spring Resort, before entering the town of New Gloucester in Cumberland County.

SR 122 passes through the northern edge of the town before re-entering Androscoggin County and the city of Auburn.

SR 122 passes over the Maine Turnpike (Interstate 95) without an interchange, then turns east to end at Danville Junction southwest of the city.

Access to the Turnpike is available via the nearby exit 75 interchange with US 202/SR 4/SR 100.

[2] SR 122 has retained its routing since its original designation in 1925.