Heading out of town almost due north, the highway roughly parallels SR 5 for its southernmost five miles (8 km).

The highway crosses between the western edge of Hiram and northeastern corner of Porter twice before entering Brownfield.

The highway continues east as West Main Street into downtown, where it ends at an intersection with SR 117.

The first highway in Maine designated SR 160 was located in the extreme northern part of the state and ran between Saint Francis and Madawaska in 1925.

Highways in 1926, the eastern end of the route was truncated to Fort Kent, with part of it becoming the northernmost stretch of US 1.