After entering the city of Bangor, more businesses begin to line the road as it widens to four lanes.

Continuing southeast, the highway narrows to two lanes again and enters a residential neighborhood.

[2] The road continues as Union Street which connects with US 1A / SR 9 and crosses the Penobscot River into Brewer.

[2] The SR 222 designation was first used in 1931 for a new routing in connecting US 1 in Caribou to the Canadian border east of Fort Fairfield.

[4] The modern SR 222 was designated in 1936 on a new routing between Corinna and Bangor, and its alignment has not changed since.