The highway heads north, later northeast, through a mostly wooded area in the central part of the state.

In front of an elementary school, the road crosses into the town of Etna.

[1] Continuing through Etna, the highway climbs a small hill before descending again to an intersection with US 2 and SR 100.

Past this intersection, the road continues downhill crossing a railroad at the center of the Etna settlement.

SR 143 resumes passing through a rural area passing to the west of a campground and Pleasant Lake before entering the community of Stetson and ending at SR 222.