The two routes run concurrent for two miles (3.2 km) before they split apart not far north from Winthrop.

Two miles (3.2 km) later, SR 41 splits north also in Readfield.

SR 41 passes through Vienna and then enters Franklin County.

SR 41 passes through the extreme southwestern corner of New Sharon near Crowell Pond and meets the southern terminus of SR 134 before entering Chesterville.

Continuing north, SR 41 meets the eastern terminus of SR 156 just before crossing into Farmington, and ends shortly thereafter at the intersection with Farmington Falls Road (US 2/SR 27).