Its northern terminus is located east of Eddington at State Route 9.

It runs almost directly on the border for 1 mile (1.6 km) before turning northward into Bucksport.

SR 41 crosses through the western edge of Dedham and then the eastern edge of Holden, where it crosses US 1A.

SR 41 crosses into Eddington where it runs along the east side of the Holbrook and Davis Ponds before reaching its northern terminus at SR 9.

The remainder of its northern segment was renumbered SR 46.