Prior to Twiztid, Jamie Spaniolo and Paul Methric were members of the hip hop trio House of Krazees alongside Bryan Jones.

[3] After the split, Methric and Spaniolo sent a demo tape to Insane Clown Posse member Joseph Bruce (Violent J), which also featured their friend Chris Rouleau (Blaze Ya Dead Homie), under the name ISI (Infamous Superstars Incorporated).

[3] Bruce was extremely impressed, invited Methric and Spaniolo to perform on The House of Horrors Tour, and signed them to Psychopathic Records.

[9] After the release of the Mostasteless albums, Twiztid continued to build their fanbase within the juggalo community by performing at numerous shows and being involved with associated projects.

Another project formed was Psychopathic Rydas, which was a supergroup that consisted of Twiztid, Insane Clown Posse, Blaze Ya Dead Homie, and Myzery.

It consisted of studio outtakes, cut songs from the original Mostasteless album, and 1990s tracks from the House of Krazees era.

[5] The duo's close friend and labelmate Blaze Ya Dead Homie released his full-length debut in 2001 titled 1 Less G n da Hood.

Alongside Twiztid and Insane Clown Posse, Marz and Blaze Ya Dead Homie had solidified the lineup as well.

AllMusic reviewer Bradley Torreano praised the EP, writing that "Despite the fact that few outside of the juggalo family will give this a chance, this might be one of the most accurate portrayals of the mood of most unhappy young people in 2002".

Footage from the tour was incorporated into a webshow that was hosted by Twiztid titled The Purple Show, which also featured skits and backstage antics.

[12] AllMusic reviewer Rob Theakston panned the album, writing that it "is much, much better than the last ICP card record, but looking at the forest from the trees, that really isn't saying much anymore".

The event also featured Blaze Ya Dead Homie, Anybody Killa, JD Tha Weed Man, and the duo's former House of Krazees partner The R.O.C.

The album featured guest appearances from rappers signed to independent record labels, such as The Dayton Family, Tha Dogg Pound, Hed PE frontman Jared Gomes, Tech N9ne, and Krizz Kaliko.

became the third-highest-charting album in Psychopathic Records history, after Insane Clown Posse's The Amazing Jeckel Brothers and Bang!

In regards to other Twiztid albums, A New Nightmare had the largest amount of featured performers, such as Blaze Ya Dead Homie, JellyRoll, Wrekonize, Caskey, Johnny Richter, Swollen Members, The R.O.C., and others.

Twiztid and Blaze Ya Dead Homie reunited with Insane Clown Posse for the Dark Lotus album The Mud, Water, Air & Blood in 2014.

On October 21, 2014, Blaze Ya Dead Homie released his fifth full-length album titled Gang Rags: Reborn.

The members consisted of keyboardist Tiffany Lowe (Combichrist), guitarist Rocky Sobon (Ventana), and drummer Sean "Drayven" Davidson (Static-X/Davey Suicide).

[19] From Twiztid and Blaze Ya Dead Homie's Psychopathic Records departure in 2012 up until 2016, they had continued to perform at the annual Gathering of the Juggalos.

The signing had permanently severed all of Twiztid's ties to Psychopathic Records and Insane Clown Posse, including appearances at the Gathering of the Juggalos, studio collaborations, and tour plans.

Special guests included professional wrestlers such as Booker T, Scott Hall, Eric Bischoff, and Brother Love; horror icons such as Bill Moseley, Kane Hodder, and Tony Moran; comedic actors such as Brian O'Halloran and Jason Mewes; and metal musicians such as Carla Harvey.

Due to the more positive reception than their 2003 appearance, they were invited back the following year; however, the 2019 cycle ended up being the final Van's Warped Tour since it was then retired as an entity.

On April 20, 2020, Twiztid released their 13th full-length studio album Mad Season on their online web store without any prior promotion.

Twiztid also formed another supergroup in 2021 named East Side Ninjas, which featured the duo, Blaze Ya Dead Homie, and Anybody Killa.

[28] Madrox released an additional solo album on January 31, 2025 as well, named More Music You Don't Wanna Hear From Someone You Barely Like.

[29] At 2024's Astronomicon, Twiztid confirmed that their rock-oriented album with producer Zeuss (who has worked with Rob Zombie, Earth Crisis, Hatebreed, Chimaira, among other rock/metal artists) was due for release in 2024, entitled Welcome to Your Funeral.

[32] The tour with Coal Chamber was subsequently cancelled due to health issues with the band's frontman, but Twiztid kept February 14, 2025 as Welcome to Your Funeral's release date.

[33] Jamie Spaniolo described his lyrical style by saying, "Think of it as if there was a Halloween or Friday the 13th on wax and Jason and Michael Myers could actually rap, this is what their vibe would sound like".

[40] Methric was more of a hip hop fan and Spaniolo was more into rock music when the duo were younger, with the latter stating, "I’m the guy that likes The Beatles or Frank Sinatra.

[40] The duo has stated that they are collectively influenced by Rob Zombie, Sully Erna, Chester Bennington, Black Sabbath,[24] Marilyn Manson, Ronnie James Dio, Alice In Chains, Seether, Bullet for My Valentine, Korn, Mudvayne, Papa Roach, P.O.D., Slipknot, Five Finger Death Punch, and Bring Me the Horizon.