The manga was originally serialized in Shueisha's Weekly Shōnen Jump from February 2005 to April 2009, with its chapters collected in 23 tankōbon (bound volumes).

To create the atmosphere of the series, Matsui used as reference paintings by Rei Kamoi, a Japanese artist he saw on television, and Gōjin Ishihara, the illustrator of Edogawa Ranpo's Shōnen Tantei Dan.

Matsui's creative process of art is to begin drawing erotic and grotesque images and at the same time humorous and cute scenes.

[7] As such, elaborating on "why people would create such complex tricks in order to murder someone, [he] wanted to convey the extent to which humans will go in pursuit of a goal".

[8] Written and illustrated by Yusei Matsui, the manga was originally serialized by Shueisha in the Japanese magazine Weekly Shōnen Jump from February 21, 2005,[9] to April 20, 2009.

[21][22] Outside Japan, it has been licensed in some countries such as in France by Glénat,[23] in Hong Kong by Culturecom,[24] in Italy and Spain by Planeta DeAgostini,[25][26] in South Korea by Seoul Media Group,[27] and in Taiwan by Tong Li Publishing.

Dream Partners and VAP and directed by Hiroshi Kōjina, with Satoshi Suzuki handling series composition, Mika Takahashi designing the characters and Tomoki Hasegawa composing the music.

[37] The series was acquired by Viz Media, which renamed it Neuro: Supernatural Detective and streamed it from February 18, 2011, to July 1, 2011, on its website VizAnime.com, and on Hulu.

[41][42] A light novel titled Majin Tantei Nōgami Neuro: Sekai no Hate ni wa Chō ga Mau[Jp 1] was written by Akira Higashiyama and published by Shueisha on July 20, 2007.

[45] In Japan, action figures, bags, chawan, T-shirts, mouse pads, fridge magnets, and other products were sold as merchandise for the series.

[46] Neuro Nōgami appeared in the Nintendo DS game Jump Ultimate Stars as a battle character, using Yako for some of his attacks.

Japanese website New Akiba, hosted a petition intended to show fans' dissatisfaction and to ask Madhouse and Nippon Television to be more faithful to the original work.

"[57] Anime News Network's Carlo Santos said that the series walks "the line between serious sleuth drama and supernatural spell-fest", "balancing all that with the occasional joke".

[58] Serdar Yegulalp from About.com said it has "[a]n interesting concept", is "competent enough", and "has a few fun twists", but that apart from the supernatural elements it does not bring anything that has not already been done in Case Closed.

Beveridge added it "has some good production values", but criticized Neuro's appearance, "which is bordering on comical" as it makes it difficult for the series "to go a darker route".