Major League Quadball was founded in 2014 by Ethan Sturm, who joined with Amanda Dallas in hopes of elevating the sport of quidditch to higher levels of competition.

[4] In December 2021, US Quadball (USQ) and Major League Quadball (MLQ) announced their intention to change their names to distance themselves from Harry Potter author J.K. Rowling's views on transgender people and to avoid potential legal battles with film studio Warner Bros., the distributor of the Harry Potter films and the owner of trademarks on the word "Quidditch".

The five teams in the North Division are the Minneapolis Monarchs, Chicago Prowl (previously the Indianapolis Intensity), Detroit Innovators, Cleveland Riff, and Toronto Raiders.

The East Division includes all MLQ teams in the geographic Northeast and Mid-Atlantic regions, plus Ottawa.

The five teams in the East Division are the Boston Forge, Charlotte Aviators, New York Titans, Washington Admirals, and Ottawa Black Bears.

The North Division was composed of the Cleveland Riff, Detroit Innovators, Indianapolis Intensity, and Rochester Whiteout, and the East Division was composed of the Boston Night Riders (now the Boston Forge), New York Titans, Ottawa Black Bears, and Washington Admirals.

MLQ had an extremely successful first season, picking up partnerships with Savage Apparel (now VII Apparel), Peterson's Brooms, and Destination Toledo, holding 12 regular-season, three-game series, and hosting the 2015 MLQ Championship in Toledo, Ohio.

In the 2016 season, MLQ doubled the size of the league to 16 teams and geographically expanded it with the creation of the South and West Division.

In 2024, MLQ indefinitely paused operations for the Rochester Whiteout franchise, citing a lack of quadball infrastructure in the Rochester area, as well as trouble fielding full rosters in previous seasons, and the departure of the team's head coach.

Departments include: Gameplay; Finance; People Operations; Marketing; Creative; Digital Media; Diversity Equity & Inclusion; and Events.

The West Division was eliminated at the end of the 2018 season due to extensive travel time for the teams.

With the addition of Charlotte in 2021 (and their retention for 2022), and the return of Toronto and Ottawa for 2022, Rochester was moved back into the North Division.

^The Charlotte Aviators temporarily joined the East Division as an MLQ Trial Expansion Team* for the 2021 season and were invited to return in the same capacity in 2022.