The species, considered "endangered" by the International Union for Conservation of Nature (IUCN), is currently restricted to isolated mountain streams in the island's Serra de Tramuntana and has an estimated population of 500 to 1500 breeding pairs in the wild.

[citation needed] The Majorcan midwife toad is thought to have disappeared from most of the island as a result of the introduction of competitors and predators from the mainland in ancient times.[who?]

[2] Alytes muletensis faces several significant threats to its survival, primarily attributed to human-induced factors and the introduction of non-native species.

Additionally, competition for territory with the introduced Perez's frog (Rana perezi) exacerbates the challenges faced by the Mallorcan midwife toad.

Moreover, high human pressure on karstic creeks for recreational purposes creates the potential for the spread of disease agents, endangering the Mallorcan midwife toad.

Although the prevalence of Batrachochytrium dendrobatidis (Bd) reportedly declined between the 2008 and 2020 IUCN assessments, captive-bred individuals are still being released, posing the risk of introducing new diseases to wild subpopulations.