Makrakomi (Greek: Μακρακώμη) is a town and a municipality in the western part of the Phthiotis regional unit, in Greece.

[2] Makrakomi is built on the southern slopes of Western Othrys at an altitude of 280 m. It overlooks the river Spercheios and its valley.

Makrakomi is located east of Karpenisi, ENE of Agrinio, south of Karditsa, west of Lamia and the GR-1/E65 and the E75 as well as the GR-3 and WNW of Amfissa.

"Makra Kome" is mentioned by the historian Livy (Titus Livius) in his description of the destruction of Sperchias by the Aetolians (198 B.C) (see Macra Come).

Sights include the church of Agia Paraskevi (set in an overgrown site with cypress trees), the Acropolis of Makrakomi (which affords a splendid view over the plain) and the hillock of Lavanitsa.

The taverns and restaurants in Makrakomi and the surrounding villages serve kokoretsi, splinantero, kontosouvli (skewered and grilled meats) and other local specialities.