Evrytania also features a famous skiing resort located near Karpenisi on the Tymfristos mountain.

The Greek National Road 38 from Agrinio to Lamia passes through the southern part of Evrytania and the town Karpenisi.

In the aftermath of the Fourth Crusade in 1204 it became part of the Despotate of Epirus, which was conquered by the Ottoman Empire around 1450.

Unlike other parts of Greece at the time, while the eastern and the southern parts were definitively ruled by the Ottomans, the area around Agrafa managed to sustain complete autonomy due to the difficulties experienced in conquest of the region.

Peace finally returned to Evrytania at the end of the 1940s and its economy expanded, though there was significant migration from the villages to cities.