Makrygianni or Makriyanni (Greek: Μακρυγιάννη, pronounced [makriˈʝani]) is a neighborhood of Athens, Greece.

The district is named after Ioannis Makrygiannis, Greek general of the Greek War of Independence, who used to own a house and fields in the area.

Opposite the house of Ioannis Makrygiannis a military hospital was built – known as Weiler Building after the architect who designed it.

[1][2] This building was later used as gendarmerie headquarters and a violent battle took place there during the Dekemvriana, in 1944.

In the Makrygianni neighbourhood is located the new Acropolis Museum that was inaugurated in 2009.