The Malayan High School of Science (MHSS) is a private secondary educational institution established in 2005.

It is on a one-hectare property along P. Guazon Street (formerly Otis St.) in the district of Pandacan, Manila, Philippines.

The inauguration of MHSS was held on January 16, 2006, with then Manila Mayor Lito Atienza as guest speaker and MIT chairman Alfonso T. Yuchengco, former Senate president Jovito Salonga, former Prime Minister Cesar Virata, and Yuchengco Group of Companies (YGC) chairperson Helen Y. Dee in attendance.

The school opened its doors to 312 freshmen students and formally launched its first year of operation on June 14, 2006 under the administration of president, Dr. Reynaldo B. Vea, who is also the president of MIT.

MHSS is accredited by the Mathematics Teachers Association of the Philippines (MTAP) to be the only mathematics review center for Grade 6 and high school students in Manila.