This promulgated an annual scholarship examination that formally established the UB Science High School as an institution of specialized secondary education.

With the implementation of the K to 12 program in 2013, the school has since established the Senior High School department which exclusively offers the Academic Track with the following strands: Science, Technology, Engineering & Mathematics (STEM), Accountancy, Business & Management (ABM), and Humanities & Social Sciences (HUMSS).

The gray and red wrap-around skirt donned by the female students are iconic to the school.

Certain Latin words and phrases have also been imbued in the scholars' vocabularies, such as haustus which refer to their morning and afternoon breaks, and festina lente which means to make haste slowly.

Aside from academic excellence, the school enables a culture that fosters servant-leadership and independence through its unique practices and traditions.